Ultrafiltration and Selective Reabsorption in the Kidney

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Arpita Srivastava

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Kidneys are the main organs of the excretory system, located on either side of the spine. They separate nutrients from waste material and flush the waste out of the system.

  • The kidneys are reddish-brown bean-shaped organs that consist of the renal artery, renal vein, and ureter.
  • The nephrons are complex, tubular, functional structures within the kidneys. 
  • Urine formation in the nephrons is a result of three processes namely ultrafiltration, selective reabsorption, and secretion.
  • The principle of ultrafiltration is filtering solutions under high pressure while passing them through a membrane with minute pores.
  • The membrane allows smaller particles to pass through them while the larger particles are retained.

Selective reabsorption is the process where molecules that are filtered out nitrogenous waste products are reabsorbed from the filtrate as they pass through the nephron.

Key Terms: Ultrafiltration and Selective Reabsorption in the Kidney, Ultrafiltration, Selective Reabsorption, Kidney, Nephron, Excretory System, Urine, Bowman’s capsule


Ultrafiltration

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One of the main functions of the nephrons is urine formation and, eventually, the excreting of toxins from the body in the form of urine. The nephrons separate the nutrients in the blood from the waste material. 

  • Ultrafiltration of blood can be defined as the first of the three processes taking place within the nephrons.
  • In this process, metabolic wastes from the blood are separated, and urine is formed. 
  • The glomerulus, efferent arterioles, and Bowman’s capsule are the structures present in the nephrons that perform the process of ultrafiltration. 
  • Filtration membrane will allow water and small solutes to pass through the kidney but blocks blood cells and large proteins. 
  • The nutrients from the filtrate that are formed as a result of the ultrafiltration process are reabsorbed by the renal tubules of the nephrons.
  • The ultrafiltrate will be passed through the proximal tubule, the convoluted tubule, and a series of ducts to form urine.

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Process of Ultrafiltration

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Ultrafiltration occurs in the Bowman’s capsule, a cup-like structure in the nephron that encloses the glomerulus. Blood is filtered under high pressure in this capsule. 

  • A glomerulus can be defined as a collection of tiny capillaries that branch out from an efferent arteriole. 
  • Blood from the glomerulus is again carried away from the Bowman’s capsule by another efferent arteriole.
  • The first step in urine formation is the filtration of blood by the glomerulus, known as glomerular filtration. 
  • Here, blood filtration occurs due to high blood pressure in the capillaries. 
  • The filtration process occurs through 3 layers, namely the endothelium layer of the blood vessels of the glomerulus, the epithelium layer of the Bowman’s capsule, and the basement membrane between the two layers. 
  • The epithelium cells in the Bowman’s capsule are arranged in such a way that blood passes through these membranes and gets filtered. 
  • The filtration is so fine that most of the blood's constituents, with the exception of proteins, are restored in the Bowman’s capsule. 
Ultrafiltration

Ultrafiltration


Applications of Ultrafiltration 

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The applications of ultrafiltration are as follows:

  • The ultrafiltration principle is used in hemodialysis machines when blood pressure is higher than the dialysate pressure.
  • This process helps to separate fluid from blood without disturbing the blood cells.
  • Slow Continuous Ultrafiltration (SCUF) is a renal replacement therapy that is based on the principle of ultrafiltration.
  • The therapy is used to remove fluid continuously for patients with kidney failure.
  • The principle of ultrafiltration is also used in the chemical, pharmaceutical, and manufacturing industries and for wastewater management.

Selective Reabsorption

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Selective reabsorption is the second step in urine formation. It happens in the proximal tangled tubule, which retains certain particles from the glomerular filtrate back in the blood.

  • Selective reabsorption is carried out in the PCT (proximal convoluted tubule).
  • The PCT cells contain various mitochondria which provide ATP for the process of active transport.
  • The glomerulus is used to filter water and small solutes out of the bloodstream. 
  • The selective reabsorption is maximum in the PCT of the nephron.

Process of Selective Reabsorption

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Selective reabsorption is carried out in the proximal convoluted tubule and loop of Henle. The PCT cells have microvilli, which are finger-like extensions and also called the brush-bordered epithelium. 

  • The loop of Henle lies between PCT and the convoluted tubule.
  • Nephric filtrate is the filtrate obtained after glomerular filtration.
  • The filtrate contains substances such as glucose, amino acids and mineral salts.
  • It also contains toxic chemicals such as urea, ammonia, uric acids, and salts.
  • The nephric passes through the lumen of PCT after exiting the Bowman’s Capsule. 
  • When it passes through the PCT, then, these substances are absorbed by the nephric filtrate into the blood capillaries.
  • Reabsorption is carried out by passive and active transport.
  • Approximately 80 percent of the inorganic salts are reabsorbed into the capillaries.
  • Selective reabsorption is carried out by the process of diffusion of urea.
  • The water in the filtrate is reabsorbed by the process of osmosis. 
Selective Reabsorption

Selective Reabsorption

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Things to Remember

  • Ultrafiltration is the filtration process of a solution at high pressure, passing through a porous membrane.
  • The organs involved in the human excretory system are the kidneys, ureters, urinary bladder, and urethra.
  • The ultrafiltration process in the nephrons helps separate urine from blood.
  • Nephrons perform three processes to filter blood: glomerular filtration, reabsorption, and secretion.
  • Selective reabsorption is used to transmit useful substances back into the blood.
  • Solutes like glucose, amino acids, and vitamins are reabsorbed by either passive or active transport. 

Sample Questions

Ques. Why is kidney filtration known as Ultrafiltration? (2 marks)

Ans: Kidney filtration is known as ultrafiltration as the blood is finely filtered through the different semi-permeable layers such that most of the blood plasma components except proteins are passed to the renal tubules for reabsorption.

Second Answer

Ans. Ultrafiltration allows the kidneys to remove excess water and waste products while retaining essential components of the blood. This meticulous process ensures a healthy balance within the body's internal environment.

Ques. What is required for ultrafiltration to occur? (2 marks)

Ans: Ultrafiltration takes place when blood or any fluid is passed through semi-permeable membranes or layers under high pressure. This causes the separation of larger components from finer ones and hence results in finer filtration.

Second Answer

Ans. Ultrafiltration is a technique used to separate components in a liquid mixture. It relies on the power of pressure and semi-permeable membranes.​ The filtrate (the liquid that passes through) is essentially a more purified version of the original mixture, with the larger components removed.

Ques. What is removed during ultrafiltration? (2 marks)

Ans: Water, glucose, amino acids, sodium chloride, and urea are removed during the process of ultrafiltration. The nephrons present in the kidney are responsible for ultrafiltration of blood and reabsorption of the filtrate.

Second Answer

Ans. Smaller molecules, like water, glucose, amino acids, sodium chloride (salt), and urea (a waste product), can pass through the pores in the membrane.  Sodium chloride also undergoes controlled reabsorption, helping to regulate blood pressure and fluid balance. Waste products like urea, however, are not reabsorbed and remain in the filtrate

Ques. How ultrafiltration takes place in kidneys? (3 marks)

Ans: The ultrafiltration process takes place in the Bowman’s capsule section of the nephron. Blood flows to the glomerular capillaries from an efferent arteriole and creates high pressure causing the blood to pass through three layers of semi-permeable membranes. As the blood passes through these layers it is finely filtered and the components of the filtrate are reabsorbed into the blood through the renal tubules.

Second Answer

Ans. The Bowman's capsule region of the nephron is where the ultrafiltration process occurs. An efferent arteriole delivers blood to the glomerular capillaries, where it generates high pressure and passes through three layers of semi-permeable membranes. The blood is carefully filtered as it moves through these layers, and the renal tubules allow the filtrate's constituents to be reabsorbed into the circulation.

Ques. What is the function of Bowman’s capsule? (2 marks)

Ans: Bowman’s capsule is a structure in the nephron which is in the shape of a cup and it surrounds the glomerular capillaries. The first step in the formation of urine is glomerular filtration or ultrafiltration. The ultrafiltration of blood takes place through the membranes in the Bowman’s capsule and the further processes of absorption and secretion are carried out by other parts of the nephron.

Second Answer

Ans. Bowman's capsule surrounds a network of tiny blood vessels called the glomerular capillaries. This strategic positioning allows blood to be filtered efficiently. Blood pressure forces fluids and dissolved molecules from the glomerular capillaries into the Bowman's capsule. Larger components, like blood cells and proteins, are too big to squeeze through the membrane and remain in the bloodstream.

Ques. What is the primary function of podocytes present in the kidney? (2 marks)

Ans: Podocytes are the epithelium cells on the Bowman’s capsule that are closely arranged leaving minute spaces called slit pores through which blood is filtered finely. Therefore, the main function of podocytes in the kidney is to enable fine filtration of blood in the urine formation process.

Second Answer

Ans. Podocytes, with their intricate structure and location within the Bowman's capsule, play a critical role in selective filtration during urine formation. They act as tiny gatekeepers, ensuring essential components stay in the blood while waste products are efficiently removed.

Ques. What is kidney filtrate? (2 marks)

Ans: Kidney filtrate is a fluid that is filtered from blood during the ultrafiltration process. This fluid passes through the different parts of the nephron where most of its constituents are reabsorbed by the body through active or passive mechanisms.

Second Answer

Ans. A fluid called kidney filtrate is created when blood is filtered out during the ultrafiltration procedure. The majority of this fluid's ingredients are reabsorbed by the body through active or passive processes as it travels through the various nephron sections.

Ques. What is tubular reabsorption? (2 marks)

Ans. Tubular reabsorption is one of the three processes used for moving solutes and water out of filtrate into the bloodstream. It is called reabsorption because the substances have been absorbed a second time in the blood. The particulates are absorbed the first time from the digestive tract after a meal.

Second Answer

Ans. Tubular reabsorption is a vital process that allows the kidneys to conserve essential components while efficiently eliminating waste products. This meticulous process ensures a healthy balance within the body's internal environment. At the same time, waste products like urea (a byproduct of protein metabolism) are not reabsorbed and remain in the filtrate, ultimately becoming part of urine.

Ques. What are two different types of ultrafiltration systems in dialysis? (2 marks)

Ans. The two different types of ultrafiltration systems in dialysis are as folllows:

  • Point of use: Point of use is used for processing of under-the-counter drinking water systems.
  • Point of entry: Point of entry is used for using water for activities that do not require water as a filter.

Second Answer

Ans. The two different types of ultrafiltration systems in dialysis are as folllows:

  • Point-of-Use Systems: Treat water at the point where it's consumed (like a faucet). Examples include countertop filters and reverse osmosis systems.
  • Point-of-Entry Systems: Treat water as it enters a building, filtering the entire water supply. Examples include whole-house filtration systems.

Ques. How kidney is used for maintaining the pH of body? (3 marks)

Ans. It is determined that pH for humans lies in the range of 7.35 to 7.45. To bring the body to the required pH level, the body goes into the state of acidic or alkaline, depending on whether the amount is below or above this range. The kidney will regulate the acid and base by reabsorbing bicarbonate from the urine and excreting acid and base ions. If the pH level reaches the required limit, kidneys can store bicarbonate. Otherwise, the bicarbonate will be released if the acidity level increases.

Second Answer

Ans. It has been established that the pH range for humans is 7.35 to 7.45. Depending on whether the amount is below or above this range, the body enters an acidic or alkaline condition to bring the pH level to the necessary level. By excreting acid and base ions and reabsorbing bicarbonate from the urine, the kidney controls the levels of acid and base. Kidneys have the capacity to store bicarbonate if the pH level rises to the necessary amount. If the acidity level rises, the bicarbonate will be discharged

Ques. What is erythropoietin? (2 marks)

Ans. Erythropoietin is used to regulate the process of erythropoiesis or the formation of red blood cells. During hypoxia, erythropoiesis is released. When the level of erythropoietin decreases then kidney will reach the level of failure. This, in turn, will decrease RBC production and thus result in low haemoglobin levels (anaemia).

Second Answer

Ans. Red blood cells are vital for carrying oxygen throughout your body. Their production is regulated by a hormone called erythropoietin (EPO), primarily produced by your kidneys. It acts like a signal to your bone marrow, the factory where red blood cells are produced. With increased EPO levels, the bone marrow ramps up production of red blood cells.


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